Getting There
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Iquitos is only connected by water and air with the rest of the world and is indeed the largest town on the Amazon without road connections.
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air
There are twice daily flights to Lima for USD 59 and also flights to Caballococha for USD 40.
boat
There are boats upstream to Pucallpa every two days or less, depending on the season, for around USD 25, taking between 3 and 7 days. Ask at Bellavista, Malecon Tarapaca 596.
Downstream you can go to Tabatinga in Brazil or to Islandia. nFrom Islandia you can get a boat to Manaus, but there don't seem to be any direct boats from Iquitos.
