Due to the closeness to the capital Stockholm, the traffic connections are excellent. Commuter trains go to Stockholm every 30 minutes during daytime, and Uppsala has intercity connections to the north and south. Stockholm airport is less than 50 km away, and buses and trains go frequently (60-100 SEK).

The north-south motorway E4 passes through Uppsala, and the east-west motorway E18 is not far to the south of the city. The Swedish road authority ("vägverket") provides extensive information on the road situation on the internet.