Of all towns in Tuscany, Pisa can be reached best, because it owns the only international airport of the region, the "Aeroporto Galileo Galilei". It is directly connected to the major Tuscan cities like Florence, Pontedera, Empoli, Montecatini Terme, Pistoia, Lucca or Prato via train. To reach the city cente of Pisa, just take a stop train or the CPT (Pisa Transport Company) bus no. 3, that departs the airport every 20 minutes. For detailed info and flight schedules, please have at look at the airport webpage

by train:

Pisa's main train station is located at the southern edge of the city centre, a 30 minutes walk away from the Piazza dei Miracoli. Regular buses run from here to all quarters stopping also at the main sights. If you don't have to carry heavy luggage it's a nice walk down to the Arno river (following the pedestrian area - northward) and then up the Via Santa Maria (stroling through the historical centre) till you reach the famous Leaning Tower.

by car:

Coming from the highway Pisa is always waymarked very well. If you enter the city from the west, you will recognize the Piazza dei Miracolis's silhouette very soon (it's really overwhelming). Parking space is very limited inside the inner city. Best is to ask your hotel about best parking facilities nearby.